Rosh Internal Medicine Boost Practice Exam

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When does serum creatine kinase-MB typically peak after an acute myocardial infarction?

16-24 hours
48-72 hours
4-6 hours
8-12 hours

The correct answer is: 16-24 hours

After an acute myocardial infarction (AMI), serum creatine kinase-MB (CK-MB) levels typically peak around 16 to 24 hours post-event. CK-MB is an isoenzyme of creatine kinase that is more specific to cardiac muscle, making it a valuable biomarker for diagnosing and assessing myocardial injury. The timeline of CK-MB elevation is important in the context of AMI. After myocardial injury, CK-MB begins to rise within 4 to 6 hours, indicating the damage to the cardiac muscle. However, the peak of CK-MB occurs later in the course, at around 16 to 24 hours after the initial injury, making this timeframe crucial for monitoring. Understanding the peak timing of CK-MB helps clinicians in diagnosing acute myocardial infarctions, determining the timing of interventions, and assessing ongoing cardiac injury. Following the peak, CK-MB levels usually return to baseline within 48 to 72 hours, which also aids in understanding the recovery phase and timing for further evaluation. This timing insight allows for better management of the patient and aids in making informed decisions regarding follow-up and treatment options.